Pharmacotherapy of Insomnia with Ramelteon: Safety, Efficacy and Clinical Applications
نویسندگان
چکیده
منابع مشابه
Pharmacotherapy of Insomnia with Ramelteon: Safety, Efficacy and Clinical Applications
Ramelteon is a tricyclic synthetic analog of melatonin that acts specifically on MT1 and MT2 melatonin receptors. Ramelteon is the first melatonin receptor agonist approved by the Food and Drug Administration (FDA) for the treatment of insomnia characterized by sleep onset difficulties. Ramelteon is both a chronobiotic and a hypnotic that has been shown to promote sleep initiation and maintenan...
متن کاملEvaluation of the efficacy and safety of ramelteon in subjects with chronic insomnia.
OBJECTIVE To evaluate efficacy and safety of ramelteon (MT1/MT2-receptor [corrected] agonist) in subjects with chronic primary insomnia. METHODS Randomized, multicenter, double-blind, placebo-controlled trial of nightly ramelteon treatment (8 mg or 16 mg) in adults (N=405) with primary chronic insomnia (DSM-IV-TR). Latency to persistent sleep (LPS), TST, sleep efficiency, wake time after slee...
متن کاملRamelteon for primary insomnia
Clinical and Patient Impact • Ramelteon is a selective MT1/MT2 melatonin receptor agonist. Both these receptors are implicated in the effects of natural melatonin on sleep and circadian rhythms. An application for a Marketing Authorisation for the management of primary insomnia in adults has been submitted to the EMEA, and it is expected that any licence will allow for a maximum of six months o...
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ژورنال
عنوان ژورنال: Journal of Central Nervous System Disease
سال: 2011
ISSN: 1179-5735,1179-5735
DOI: 10.4137/jcnsd.s1611